Bioactive Small Molecules
Medchemexpress LLC BMS 310705 | 280578-49-6 | 99.1% | 522.70 g/mol | C27H42N2O6S | 10 MG
BMS 310705 (21-Aminoepothilone B) is an epothilone-derived small-molecule apoptosis inducer used in biochemical and cellular research. It is characterized by CAS 280578-49-6, molecular formula C27H42N2O6S, and high reported purity, and is supplied as a solid optimized for DMSO solubility and long-term storage.
- Epothilone-derived apoptosis inducer for cell-based assays.
- High purity (99.1%) suitable for research applications.
- Molecular weight 522.70 g/mol for accurate dosing.
- Soluble in DMSO at 100 mg/mL with sonication.
- Powder stable at -20°C for up to 3 years.
- In vivo formulation achievable at ≥2.5 mg/mL in mixed solvent protocol.
Medchemexpress LLC Suzetrigine phenol | 2649467-91-2 | 99.4% | 459.37 | 1 ML
Suzetrigine phenol is the phenolate form of the sodium channel modulator Suzetrigine (HY-148800). Suzetrigine (VX-548) is an orally active and highly selective inhibitor of NaV1.8. It is a highly selective, orally active sodium channel modulator for research purposes.
- Sodium channel modulator
- Orally active
- Highly selective inhibitor of NaV1.8
- Appearance: solid, white to off-white
- For research use only
Cayman Chemical ANTIBODY CZ415 10mg
An mTOR inhibitor (Kd = 6.3 nM); 1,000-fold selective for mTOR over a panel of 285 kinases; inhibits phosphorylation of S6RP and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively); inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM); reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis at 10 mg/kg; inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model at 20 mg/kg
Cayman Chemical ANTIBODY MF438 10mg
A stearoyl-CoA desaturase inhibitor (IC50 = 2.3 nM for the rat enzyme); reduces spheroid formation in NCI H460 and patient-derived NSCLC cells in a concentration-dependent manner; decreases ALDH1A1 activity in NCI H460-derived spheroids at 1 µM; acts synergistically with cisplatin to induce apoptosis and autophagy in patient-derived NSCLC cells
Medchemexpress LLC HY-N2292 5mg Medchemexpress, Kinsenoside CAS:151870-74-5 Purity:>98%
Medchemexpress, HY-N2292 5mg Kinsenoside CAS:151870-74-5 Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. Kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxidative stress and protects against apoptosis, senescence and mitochondrial dysfunction in a Nrf2-dependent way. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cell Signaling Technology FastScantm Phospho-Akt Ser473 ELISA Kit 10 Kit
FastScantm Phospho-Akt Ser473 ELISA Kit 10 Kit
Cayman Chemical ANTIBODY BrazIlIn 10mg
A flavonoid with diverse bioactivities; inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 µM); prevents Aβ (1-42) mature fibril remodeling; inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 µM); effective against Gram-positive and Gram-negative bacteria MICs = 31.3-250 UG/ml; inhibits RANKL-mediated osteoclast differentiation; protective against LPS-induced osteoporosis in mice (100 mg/kg)
Cayman Chemical MarcfortIn A 5mg
An anthelmintic; has nematocidal activity against H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM); eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively); dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing and muscle-type nAChRs, respectively
Cayman Chemical 4bromoaMethylamInovaleroph 5mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Medchemexpress LLC YAP/TAZ inhibitor-2 | 2762617-31-0 | 99.8% | 390.33 | 25 MG
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. It demonstrates anti-proliferative and antitumor activity.
- Exhibits antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells
- Shows anti-tumor activity in BALB/c nude mice (NCI-H226 xenograft model)
Medchemexpress LLC Ensifentrine | 1884461-72-6 | ≥95.0% | 10MM 1ML
Ensifentrine | 1884461-72-6 | ≥95.0% | 10MM 1ML
Cayman Chemical ANTIBODY SpInosad 50mg
A naturally-occurring insecticide; a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nAChRs; induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC50s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 UG/ml, respectively); has low toxicity in vertebrates; inhibits canine P-gp (IC50 = 0.2 UG/ml)
Medchemexpress LLC N-Phthaloyl-β-alanine | 3339-73-9 | 219.20 | 5 G
N-Phthaloyl-β-alanine is an FX-type hapten without a CH2S moiety. It can be coupled to OVA using the mixed anhydride method and exhibits more heterologies. It is for research use only.
- FX-type hapten without a CH2S moiety
- Can be coupled to OVA using the mixed anhydride method
- Exhibits more heterologies
- For research use only
Cayman Chemical Genz-644282 10MG
An inhibitor of topoisomerase I that inhibits topoisomerase I-mediated DNA cleavage 10-fold more potently than topotecan; inhibits the growth of and is cytotoxic to human and mouse bone marrow cells in vitro (IC50s = 0.4 and 2.3 nM, respectively; IC90s = 1.2 and 8.4 nM, respectively); inhibits the growth of and is cytotoxic to human tumor cell lines in vitro (IC50s = 0.15-2 nM; IC90s = 0.7-8.3 nM); inhibits tumor growth in mouse xenograft models (1.36-2.7 mg/kg)
![Medchemexpress LLC 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole | 163239-22-3 | 99.5% | 238.26 g/mol | C15H11FN2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264296.png-250.jpg)
Medchemexpress LLC 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole | 163239-22-3 | 99.5% | 238.26 g/mol | C15H11FN2 | 5 MG
680C91 is an orally active, selective small-molecule inhibitor of tryptophan 2,3-dioxygenase (TDO) used as a research reagent to probe tryptophan catabolism and its role in cancer immunotherapy and neurodegenerative disease. It is reported with a Ki of 51 nM, molecular formula C15H11FN2, and is supplied as a powder for laboratory use.
- Selective TDO inhibition (Ki ~51 nM)
- Orally active small molecule suitable for in vivo and in vitro studies
- Molecular weight 238.26 g/mol, formula C15H11FN2
- High reported purity on manufacturer product page
- Supplied as a powder with recommended cold storage
- Applicable to cancer immunotherapy and neurodegenerative disease research